Climbazole is a topical antifungal agent commonly used in the treatment of human fungal skin infections such asdandruff and eczema. Climbazole play an important role in the pathogenesis of dandruff. It is most commonly found as an active ingredient in OTC anti-dandruff and anti-fungal products, including shampoos, lotions and conditioners. It may be accompanied by other active ingredients such as zinc pyrithione or triclosan.
Zinc Pyrithione is a coordination complex of zinc. It has fungistatic (that is, it inhibits the division of fungal cells) andbacteriostatic (inhibits bacterial cell division) properties and is used in the treatment of seborrhoeic dermatitis. Zinc pyrithione is best known for its use in treating dandruff and seborrhoeic dermatitis. It also has antibacterial properties and is effective against many pathogens from the Streptococcus and Staphylococcus genera. Its other medical applications include treatments of psoriasis, eczema, ringworm, fungus, athletes foot, dry skin.
Triclosan is an antibacterial and antifungal agent found in consumer products, including soaps, detergents, surgical cleaning treatments. Triclosan prevalent in soaps (0.10-1.00%), shampoos, deodorants, toothpastes, mouth washes and cleaning supplies.